Giants vs. 49ers 2023 NFL Week 3 Odds, Preview & Pick

By Jeff Stinger • September 20, 2023

For the first time this season, the San Francisco 49ers will be hosting a game in Santa Clara and under the primetime lights of Thursday Night Football all the more. They’ll be taking on the New York Giants, who nearly escaped disaster in Week 2 and are in a tough road matchup against arguably the best team in the league right now.

Nitrobetting is ready to take your bets into the end zone this 2023 NFL season. Let’s take a closer look at the upcoming Week 3 NFC clash between the New York Giants and the San Francisco 49ers.

Giants vs. 49ers Game Information

Rockin' the red #94Niners throwbacks on Thursday Night Football #TNFonPrime x #NYGvsSF
— San Francisco 49ers (@49ers) September 19, 2023

When: Thursday, September 21, 2023, 4:05 PM ET
Where: Levi’s Stadium, Santa Clara, CA
TV: Amazon Prime Video
Radio: WFAN 101.9 FM (Giants) // KSAN 107.7 The Bone (49ers)
Live Stream: NFL Game Pass
NFL Odds: Giants (+10) // 49ers (-10)

Why Bet on the New York Giants?

After being down 20 points in halftime, the New York Giants managed to dig themselves out of that deep hole and managed to pull away with an almost miraculous 31-28 victory over the Arizona Cardinals in Week 2. New York avoided falling to 0-2 to start its season but it did come at a hefty cost.

Star running back Saquon Barkley was a beast on the ground as expected, piling up 17 carries for 63 rushing yards and a touchdown. Unfortunately, Barkley suffered an ankle injury and will be out of action for the next few weeks at the very least. On the bright side, the passing game looked much better this past week, with Daniel Jones completing 26 of 37 passes for 321 yards and a pair of passing TDs, albeit with one interception.

The Giants exposed a weak Arizona defense in the second half, yet they’ll be facing a much tougher defensive unit this Thursday night. Their defense will have its hands full as well, as New York’s league-worst 34.0 points allowed per contest does not bode well for their chances at an upset in the Bay Area.

Why Bet on the San Francisco 49ers?

In a closer bout than what many expected, the San Francisco 49ers still picked up a huge road win over their California rivals the Los Angeles Rams this past Sunday, 30-23. San Francisco remains undefeated to start the new season and is still widely regarded as one of if not the best team in the NFL right now.

It was another fantastic performance for the Niners’ running game, which gashed the Rams for 159 rushing yards and three touchdowns on 28 carries, with stud back Christian McCaffrey leading the way with 116 rushing yards and a rushing TD. Brock Purdy was efficient once more under center, going 17-of-25 for 206 passing yards, no turnovers, and one rushing score.

What’s a bit of a concern for the 49ers is that their defense allowed the Rams to throw for over 300 passing yards and convert seven of their 14 third-down opportunities. Thankfully, a pair of late takeaways allowed the Niners to hang onto their 10-point lead at the start of the final quarter. San Francisco is currently tied for third in the league allowing just 15 points per game, and this defense will get to regroup against a Giants often missing its best weapon yet again.

Giants vs. 49ers Betting Trends

The Giants are 2-4 in the last six road games (4-2 ATS).
The G-Men are 3-4 in its last seven meetings against San Fran since 2001 (2-5 ATS).
The totals went over in each of the last four NYG-SF matchups.
The 49ers are undefeated in the last eight home games, including the playoffs (7-1 ATS).
The Niners are 4-1 in its last five games played against NFC East teams (SU/ATS).
The totals went over in five of the last six games played in Levi’s Stadium.

Giants vs. 49ers Expert Betting Predictions

As daunting as the double-digit spread may seem on paper, the smart money is still on the 49ers to blow out the Giants sans Barkley in the backfield. The Niners would’ve also covered last week’s spread had it not been for a late, garbage-time Rams field goal, and they’ll be even more determined than the Giants to get a win by having the home-field advantage and a much healthier roster intact.

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*All stated odds are subject to change without prior notice.