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2022 NFL Week 12 Odds, Overview & Picks

By Hank Blaine

The NFL’s annual Thanksgiving slate of games should produce great football action. The festivities start early when the Detroit Lions host the Buffalo Bills. After Lions versus Bills, the Dallas Cowboys host the New York Giants. Then at night, the Patriots travel to Minnesota to take on the Vikings. Check out the NFL odds, analysis, and free picks for eight of the best matchups in NFL Week 18.

Check out the latest NFL odds, analysis, and free picks for eight of the best games happening in NFL Week 12.

Top 2022 NFL Week 12 Games to Bet

READ MORE: 2022 NFL Week 12 Fantasy Waiver Wire Picks

Buffalo Bills vs. Detroit Lions

  • When: Thursday, November 24th, 2022. 12:30pm EST.
  • Where: Ford Field, Detroit, MI
  • NFL Odds: Bills (-9.5) // Lions (+9.5)

The Bills remain one of the better teams in the NFL. But although Buffalo is 7-3 straight up, their record against the spread leaves much to be desired.

Buffalo is 5-4-1 ATS. On Thursday, they face a 4-6 Lions squad that is on a 3-game winning streak both SU and ATS. The Lions will have a chance to win this straight up.

2022 NFL Week 12 Pick: Detroit Lions

New York Giants vs. Dallas Cowboys

  • When: Thursday, November 24th, 2022. 4:30pm EST.
  • Where: AT&T Stadium, Arlington, TX
  • NFL Odds: Bills (+9.5) // Lions (-9.5)

Last week, Detroit exposed a Giants’ squad that had entered the contest with a 7-2 record. The Lions blasted NYG 31-18.

Dallas scored 40 points in a 40-3 beating of Minnesota in their week 11 game. The Cowboys are rolling right now. It’s tough to give a Brian Daboll coached squad almost 10 points, but these two are moving in the opposite direction.

2022 NFL Week 12 Pick: Dallas Cowboys

New England Patriots vs. Minnesota Vikings

  • When: Thursday, November 24th, 2022. 8:20pm EST.
  • Where: U.S. Bank Stadium, Minneapolis, MN
  • NFL Odds: Patriots (+3) // Vikings (-3)

Detroit exposed the Giants and Dallas exposed Minnesota. On Thursday night, the Vikings hope to get back on the winning track versus New England.

Based on the odds, another Minny loss could be in store. Although the Vikings are 8-2 SU, they’re just 4-5-1 ATS, a sign that the ball has bounced their way for most of the season. It’s going to be very difficult for Kirk Cousins and his mates to score against Bill Belichick’s defense. Give the Patriots the nod.

2022 NFL Week 12 Pick: New England Patriots

Cincinnati Bengals vs. Tennessee Titans

  • When: Sunday, November 27th, 2022. 1:00pm EST.
  • Where: Nissan Stadium, Nashville, TN
  • NFL Odds: Bengals (-2) // Titans (+2)

Cincinnati has picked it up big time. But before we praise the Bengals too much, it’s important to note that Cincy’s offensive line has allowed 32 sacks in 10 games. That’s more than 3 sacks each contest.

Joe Cool can’t perform his magic when he’s laying on his back. Tennessee is the most balanced team in the NFL. The Titans play great defense, have an amazing rushing attack, and a solid quarterback. The odds make the home squad more than playable.

2022 NFL Week 12 Pick: Tennessee Titans

Atlanta Falcons vs. Washington Commanders

  • When: Sunday, November 27th, 2022. 1:00pm EST.
  • Where: FedExField, North Englewood, MD
  • NFL Odds: Falcons (+4) // Commanders (-4)

The Falcons are 1-4 straight up on the road. The ATL is 3-2 ATS so if you really want to back the Southern Birds, at least they’re positive against the spread in road games.

Still, it’s hard to look past the scorching Commanders. D.C. has won 2 straight and 5-of-6. The Commanders are also 5-0-1 against the spread in their last 6 games.

2022 NFL Week 12 Pick: Washington Commanders

New Orleans Saints vs. San Francisco 49ers

  • When: Sunday, November 27th, 2022. 4:25pm EST.
  • Where: Levi’s Stadium, Inglewood, CA
  • NFL Odds: Saints (+9.5) // 49ers (-9.5)

In the Mexico City game this past Monday night, the San Francisco 49ers dusted the Arizona Cardinals 38-10. The Cards had no answer for Jimmy Garoppolo and the Niners’ D.

Ah, but Kyler Murray didn’t play. Neither did wide receiver Marquise Brown. Colt McCoy and Trace McSorley each through a pick.

The Saints looked great in a 27-20 win against the Rams. New Orleans versus San Francisco is an old school rivalry that harks back to the days when the Big Easy played in the NFC West. The Saints will be fired up for this. New Orleans covers.

2022 NFL Week 12 Pick: New Orleans Saints

Green Bay Packers vs. Philadelphia Eagles

  • When: Sunday, November 27th, 2022. 8:20pm EST.
  • Where: Lincoln Financial Field, Philadelphia, PA
  • NFL Odds: Packers (+7) // Eagles (-7)

Some believe it’s an overreaction to say the Eagles could be in some trouble. But here’s the thing, Philadelphia allows over 122 rushing yards per game on average. When you allow that many rushing yards per game, yes, you could be in trouble.

Green Bay rushes for 122.6 each matchup. If the Eagles can’t stop Green Bay’s rush, Aaron Rodgers will be more than happy to hand the ball to AJ Dillon and Aaron Jones. Don’t be surprised when the Packers have a chance to win this straight up late in the game.

2022 NFL Week 12 Pick: Green Bay Packers

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*All stated odds are subject to change without prior notice.