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Colts vs. Broncos 2022 NFL Week 5 Odds, Preview & Pick

By Hank Blaine

The Thursday night NFL game this week is the first meeting between potential future Hall of Fame quarterbacks Matt Ryan of the Colts and Russell Wilson of the Broncos as AFC foes. Both were traded to their new teams this offseason.

Nitrobetting is ready to equip its bettors with the latest news, NFL betting odds, and special features for the entire duration of the 2022 NFL season. This time, let’s take a closer look at the upcoming Week 5 showdown between the Indianapolis Colts and the Denver Broncos.

Indianapolis Colts vs. Denver Broncos Game Information

  • When: Thursday, October 6, 2022, 8:15 PM ET
  • Where: Empower Field at Mile High, Denver, CO
  • TV: Amazon Primer Video
  • Radio: 107.5 FM The Fan (Colts) // KOA NewsRadio 850 AM (Broncos)
  • Live Stream: NFL Game Pass
  • NFL Odds: Colts (+3) // Broncos (-3)

READ MORE: Bengals vs. Ravens 2022 NFL Week 5 Odds, Preview & Pick

Why Bet on the Indianapolis Colts?

Colts running back Jonathan Taylor, the 2021 NFL rushing champion, hurt his ankle in Sunday’s loss vs. Tennessee. It’s not hugely serious but with the quick turnaround Taylor might not play Thursday. The All-Pro running back said Tuesday he is rehabbing furiously and has seen definite improvement since Sunday. Taylor took a hit to the lower leg on the fourth-quarter play on which he fumbled. He had 20 carries for 42 yards before leaving the game.

“I definitely do plan to play, but if you can’t go you can’t go,” Taylor said. “That’s why you have to get as much treatment as you can.”

Colts Frank Reich said Phillip Lindsay “will work into the equation” if Taylor can’t play. Lindsay spent all offseason with the Colts and was re-signed to the team’s practice squad after being a final cut during training camp. Lindsay played for both the Dolphins and Texans in 2021, rushing for 88-249-1 while averaging 2.8 YPC. Nyheim Hines would also see some additional work in Taylor’s absence. He’d be tough to trust against a stout Broncos defense.

Colts All-Pro linebacker Shaquille Leonard suffered a broken nose in addition to the concussion he was diagnosed with after Sunday’s game and he’s out at least Thursday. Defensive lineman Tyquan Lewis also will miss the game with a concussion.

Indy’s Ryan, who spent 14 seasons with Atlanta prior to joining the Colts during the offseason, ranks second among active quarterbacks in passing yards (60,860) and third in touchdown passes (372). Ryan passed for a season-high 356 yards last week and is the only quarterback in the league this season with two games of 350-or-more passing yards.

Ryan fumbled twice more on Sunday (losing one) vs. the Titans, giving him nine fumbles for the season. That’s the most fumbles by a player in his team’s first four games since Kurt Warner accomplished the dubious feat in 2006 with the Arizona Cardinals.

Why Bet on the Denver Broncos?

Both teams could be without their starting running backs. We know Denver will be as Javonte Williams as he tore up his knee in Sunday’s loss to the Raiders and will miss the season. Williams suffered his injury on the Broncos’ first play of the second half in Sunday’s 32-23 defeat. Williams, who entered the game as the Broncos’ leader in carries and rushing yards, stayed down on the field after a 1-yard loss.

Mike Boone replaced Williams in the Broncos’ lineup right after Williams went down. Melvin Gordon III had split time with Williams over the first three games of the season, but Gordon fumbled in the second quarter and the Raiders’ Amik Robertson returned it 68 yards for a touchdown. It was Gordon’s fourth fumble of the season — the Broncos have lost two of them.

Denver will also be without one of its best pass-rushers for a while in Randy Gregory. He also injured his knee Sunday but should be able to return later this season. He had posted two sacks, two forced fumbles and nine tackles through four games. In Gregory’s absence, the door is likely to open for more reps from rookie Nik Bonitto and second-year player Baron Browning.

Though Denver quarterback Russell Wilson was officially listed as “limited” on the team’s injury report for consecutive days this week with a right shoulder injury, Wilson said Tuesday he expects to be a full go for Thursday. Wilson, who has struggled at times with the transition into the Broncos offense — especially in Weeks 2 and 3 against the Texans and 49ers, respectively — threw for two touchdowns and rushed for another Sunday against the Raiders.

Wilson ranks fifth among active quarterbacks with 296 touchdown passes and in Week 4, surpassed Indy’s Matty Ryan (295) for the third-most touchdown passes by a player in his first 11 seasons in NFL history.


Denver leads the all-time regular-season series, 14-11, as the two teams meet for the first time since Week 8 of the 2019 season.

Colts vs. Broncos Betting Trends

  • Colts are 14-4-1 ATS in their last 19 Thursday games.
  • Colts are 11-5 ATS in their last 16 road games.
  • Underdog is 5-2 ATS in their last 7 meetings.
  • Broncos are 2-6 ATS in their last 8 games overall.
  • Broncos are 1-6 ATS in their last 7 games in October.
  • Underdog is 5-2 ATS in their last 7 meetings.

Colts vs. Broncos Expert Betting Predictions

Broncos moneyline.

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*All stated odds are subject to change without prior notice.