Home | News | 49ers vs. Titans 2021 NFL Week 16 Odds, Preview and Pick

49ers vs. Titans 2021 NFL Week 16 Odds, Preview and Pick

By Hank Blaine

On NFL Thursday Night Football, the San Francisco 49ers head to Tennessee to take on the Titans. Both teams are fighting for their playoff lives. Tennessee feels the Colts on their heels while the 49ers must continue to win to ensure a postseason berth. Which teams gets it done in one of the seasons’ final Thursday night games?

Nitrobetting brings you an in-depth look at the 49ers vs. Titans clash. We share timely betting and game information that point your picks in the right direction. Be sure to check out for the latest NFL odds at our online BTC sportsbook.

49ers vs. Titans Game Information

  • When: Thursday, December 23, 2021, 8:20 PM ET
  • Where: Nissan Stadium, Nashville, Illinois
  • TV: NFL Network
  • Radio: KSAN 107.7 The Bone (49ers) / 104.5 the Zone (Titans)
  • Live Stream:NFL Game Pass
  • NFL Odds: 49ers (-3.5) / Titans (+3.5)

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Why Bet on the San Francisco 49ers?

San Francisco’s offense has come to life. Since a Nov. 7 loss to the Arizona Cardinals where the Niners scored just 17 points, SF has racked up at least 23 points in their last 6 games. San Francisco scored 30 or more in wins against the Jaguars, Vikings, and Falcons. The 49ers scored 26 in an overtime win against the Cincinnati Bengals. SF averages 366.6 yards and over 25 points each game.

The 49ers’ defense has gelled. Early in the season, the Niners struggled on D. In recent games, San Francisco has played great. In Week 15, Matt Ryan and the Atlanta Falcons scored just 13 points. On Dec. 12, in NFL Week 14, Joe Burrow and the Bengals scored 23 and on Nov. 28, the 49ers held Minnesota to just 26. The defense ranks 6 th in total yards allowed, 321.8, and seventh in passing yards allowed 213.2.

Why Bet on the Tennessee Titans?

Although Derrick Henry hasn’t played since Oct. 24, the Tennessee Titans remain one of the top rushing teams in the NFL. Tennessee averages 142.3 rushing yards per, ranking 4 th in the league. The Titans’ offense averages 345.1 total yards per game. Tennessee scores a decent amount of points per, 24.1. One issue is turnovers. The Titans rank 30 th in the NFL in turnovers with 25 on the season.

Coach Mike Vrabel built Tennessee’s defense on stopping the rush. Opponents average a paltry 86.9 rushing yards per game. Once the Titans stop the rush, they turn to stopping the pass. Opposing quarterbacks are good for just 242.3 passing yards each contest. The Titans hold their rivals to 22.1 points per game.

49ers vs. Titans Betting Trends

  • 49ers are 5-1 ATS in the last 6 games.
  • San Francisco is 3-8 ATS in the last 11 Thursday games.
  • Over is 8-2 in San Francisco’s last 10 games following an ATS victory.
  • Titans are 1-4 ATS in the last 5 games.
  • Tennessee is 5-2 ATS in the last 7 games as an underdog.
  • Over is 13-5 in the Titans last 18 games following an ATS loss.

49ers vs. Titans Expert Betting Predictions

San Francisco has a 5-2 against the spread record on the road. What would you guess is Tennessee’s home record ATS? Yep, it’s 5-2. Based on the against the spread records, we should expect both teams to bring it. The biggest problem is with the betting line.

San Francisco has played better in recent games, but they shouldn’t be the favorite. SF has beaten teams like Atlanta while Tennessee has had to play against teams like Pittsburgh and New England.

The last time SF was on the road, they lost to the Seattle Seahawks. Tennessee had the game against Pittsburgh won until imploding in the fourth quarter. The Titans shouldn’t implode at home. Tennessee is good enough to win this straight up. They’re definitely worth a look to cover.

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.