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2022 NFL Week 6 Fantasy Waiver Wire Picks

By Jeff Stinger

The bye weeks are finally here, which means fantasy managers will start racing for waiver wire acquisitions this week more so than through the first four weeks of the 2022 NFL season. The Lions, Raiders, Texans, and Titans are all on byes this coming week, and there are plenty of starting roles to fill with the likes of Davante Adams, Derrick Henry, and Amon-Ra St. Brown, to name a few, as huge fantasy stars that won’t be seeing action. That being said, who are the best waiver wire options on the market right now?

Nitrobetting is ready to equip its bettors with the latest news, odds, and special features for the entire duration of the 2022 NFL season. This time, let’s take a closer look at the hottest waiver wire targets in fantasy football heading into Week 6.

Top Fantasy Football Waiver Wire Targets in 2022 NFL Week 6

READ MORE: 2022 NFL Week 6 Odds, Overview & Picks


Taysom Hill – Saints

  • Pct. Owned: 11.8%

Subpar quarterback play has been rampant through the first few weeks of the 2022 NFL regular season. But don’t tell that to New Orleans’ multi-faceted quarterback Taysom Hill, who torched the Seahawks’ defense in Week 5 with nine carries for 112 rushing yards and three touchdowns.

Although Hill rarely operates as a passer considering his natural position at QB, his upside is way higher than the Saints’ real starting quarterback Andy Dalton considering the former has five offensive TDs already. The BYU product is even eligible as a tight end in most fantasy leagues, giving him even better value as a fantasy start regardless of whether he’s a streaming QB option every week with the bye weeks at hand, or as a decent start at the flex position in deeper leagues.

Running Back

Kenneth Walker III – Seahawks

  • Pct. Owned: 47.5%

No running back is safe from the injury bug and, in Week 5, Seattle’s Rashad Penny was the latest casualty and will likely miss the rest of the season after suffering a gruesome leg injury in Week 5. In turn, rookie running back Kenneth Walker III will take over the starting running back role for the Seahawks moving forward.

Walker did a terrific job of displaying what he’s capable of as his team’s lead back, averaging 11 yards-per-carry with his 88 rushing yards and rushing TD against the Saints this past weekend. The unanimous All-American selection out of Michigan State only has to compete with DeeJay Dallas for touches in Seattle’s backfield right now, and Pete Carroll should stick with the hot hand in Walker over Dallas, especially with a huge divisional showdown against the Cardinals on tap and with Seattle being a (+2.5) home dog in the Week 6 matchup as we speak.

Eno Benjamin – Cardinals

  • Pct. Owned: 6.8%

Speaking of the Cardinals, they’re also dealing with issues at running back as well, with James Conner having to leave in the first half of the Week 5 contest against the Eagles. Third-year back Eno Benjamin filled the void left by Conner and found the end zone on one of his runs along with 53 yards from scrimmage.

Benjamin is a must-add waiver wire target this week considering Conner (ribs) and Darrel Williams (knee) both being tentative to play in Week 6. Walker is owned in more leagues right now whereas Benjamin is owned in less than 10 percent of leagues. The 23-year-old from Arizona State holds even more value in PPR leagues, as he’s seen at least four targets in Arizona’s passing game in four of the first five games of the season even with a healthy Conner in the mix.

Wide Receiver

Josh Reynolds – Lions

  • Pct. Owned: 25.0%

Although the Lions are on a bye this week as mentioned in the intro, it’s possibly worth taking a flyer on wideout Josh Reynolds right now for managers with bench room to spare. In two of his last three starts, the six-year vet saw at least 10 targets, six receptions, and no less than 92 receiving yards. In two of his last four outings where he didn’t eclipse those numbers, he managed to grab a receiving TD in each of those two games to salvage his fantasy production.

It’s clear that Jared Goff continued his solid connection with his former Rams teammate all the way to Detroit. Reynolds should not be owned in just a quarter of fantasy leagues, especially with his team’s top target Amon-Ra St. Brown recently battling with injuries. Although, picking him up on the Lions’ bye week is a judgment call to be had by managers who are already confident with their current starting lineup for Week 6.

Alec Pierce – Colts

  • Pct. Owned: 8.6%

There’s no denying that Indianapolis’ passing game has been in flux with aging Matt Ryan under center. Then again, there are flashes in the pan over in Indy, with rookie wide receiver Alec Pierce starting to get it going with Michael Pittman struggling to produce on the opposite end of the formation.

Pierce has quietly provided a stable floor of fantasy production of late. Over the past three weeks, the second-rounder out of Cincinnati has seen at least five targets and racked up no fewer than 61 receiving yards in each of those three games. He’s coming off back-to-back 80-yard outings as well, making him a decent stash even for standard-scoring leagues. The Colts should get Pierce involved on the offensive as they get an early revenge game against the rivaling Jaguars as slight (-1.5) favorites to win at home in Lucas Oil Stadium this Sunday.

Tight End

Evan Engram – Jaguars

  • Pct. Owned: 20.0%

Sticking with our theme of fantasy players on the waiver wire facing fellow waiver wire targets in Week 6, Jacksonville tight end Evan Engram will need to replicate his solid showing this past weekend in the upcoming showdown against the Colts. The former Giants first-round pick has had a career resurgence of sorts in Duval, recently setting new season-highs of 10 targets and 69 receiving yards. (Nice!)

Although Engram has yet to find the end zone this season, the mere fact that Jaguars’ offense hasn’t been utter trash this season is enough reason for him to warrant some play in fantasy. When we consider how thin the tight end position is in our favorite pastime, Engram’s decent floor of production should come as a boon to many fantasy managers as a streaming TE option with the bye weeks now in full force.

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