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2022 NFL Week 10 Odds, Overview & Picks

By Hank Blaine

The tenth week in the 2022 NFL Regular Season kicks off on Thursday, Nov. 10 when the Carolina Panthers host the Atlanta Falcons. Then on Sunday, Seattle heads to Tampa and the Vikings take on the Bills in Buffalo. On Sunday night, The Chargers travel to the 49ers. The Monday Night Game has the Eagles hoping to go 9-0 when they host the NFC East rival Commanders. Check

Check out the latest NFL odds, analysis, and free picks for eight of the best games happening in NFL Week 10.

Top 2022 NFL Week 10 Games to Bet

READ MORE: 2022 NFL Week 10 Fantasy Waiver Wire Picks

Atlanta Falcons vs. Carolina Panthers

  • When: Thursday, November 10th, 2022. 8:15pm EST.
  • Where: Bank of America Stadium, Charlotte, NC
  • NFL Odds: Falcons (-2) // Panthers (+2)

These two played a couple of weeks ago with the Falcons eking out a 37-34 win in overtime. The ATL had no business losing their last, a game versus the Chargers where they had a lead late in the fourth quarter.

Carolina is reverting back to their awful football playing ways. The Falcons are solid but the Panthers get a chance at revenge on their home field. Carolina is the play.

2022 NFL Week 10 Pick: Carolina Panthers

Seattle Seahawks vs. Tampa Bay Buccaneers

  • When: Sunday, November 13th, 2022. 9:30am EST.
  • Where: Allianz Arena, Munich, Germany
  • NFL Odds: Seahawks (+1.5) // Buccaneers (-1.5)

The Buccaneers played a great game in NFL Week 9. Tampa was down to the Los Angeles Rams. Not to be denied, Tom Brady rallied the Bucs to an impressive victory.


On Sunday, Tampa plays a better team than the Rams. Seattle is one of the best squads in the NFC. The Seahawks should win this outright.

2022 NFL Week 10 Pick: Seattle Seahawks

Detroit Lions vs. Chicago Bears

  • When: Sunday, November 13th, 2022. 1:00pm EST.
  • Where: Soldier Field, Chicago, IL
  • NFL Odds: Lions (+1.5) // Bears (-1.5)

Detroit is a bad football team. Chicago isn’t a great football team, but they have a big weapon on offense in Justin Fields.

The Bears are 2-1 against the spread in their last 3 and almost rallied to upset the Miami Dolphins in week 9. Chicago should easily cover.

2022 NFL Week 10 Pick: Chicago Bears

Jacksonville Jaguars vs. Kansas City Chiefs

  • When: Sunday, November 13th, 2022. 1:00pm EST.
  • Where: GEHA Field at Arrowhead Stadium, Kansas City, MO
  • NFL Odds: Jaguars (+9) // Chiefs (-9)

Kansas City required overtime to beat the Tennessee Titans in their last. The Titans had KC dead to rights. But Magic Man Mahomes got it done.

Jacksonville played their best game of the season in the 27-20 win against the Raiders since beating the Chargers 38-10 on Sep. 25. Expect a Jaguars’ bounce, which means KC covers.

2022 NFL Week 10 Pick: Kansas City Chiefs

Minnesota Vikings vs. Buffalo Bills

  • When: Sunday, November 13th, 2022. 1:00pm EST.
  • Where: Highmark Stadium, Orchard Park, NY
  • NFL Odds: Vikings (+5.5) // Bills (-5.5)

Buffalo hosts Minnesota a week after a tough road loss versus the AFC East rival Jets. It’s difficult to see the Bills losing 2 straight.

So Buffalo wins. Will the Bills cover? Yes because Minnesota is 3-4-1 against the spread and should have lost to the Commanders in week 9.

2022 NFL Week 10 Pick: Buffalo Bills

Dallas Cowboys vs. Green Bay Packers

  • When: Sunday, November 13th, 2022. 4:25pm EST.
  • Where: Lambeau Field, Green Bay, WI
  • NFL Odds: Cowboys (-6) // Packers (+6)

Green Bay is a bad football team. The Packers are so bad the Detroit Lions beat them 15-9 in their last.

Green Bay’s biggest issue is on offense where they average 17 points per game, but scored 9 versus the Lions and 10 against the Jets in 2 of their last 3. Dallas wins and covers.

2022 NFL Week 10 Pick: Dallas Cowboys

Los Angeles Chargers vs. San Francisco 49ers

  • When: Sunday, November 13th, 2022. 4:25pm EST.
  • Where: Lambeau Field, Green Bay, WI
  • NFL Odds: Chargers (+7.5) // 49ers (-7.5)

The Chargers got lucky in their win over the ATL. Atlanta had some suspect play calls in their final drive of the game. Also, the Falcons forced a fumble, recovered, and then lost the ball back to the Bolts.

San Francisco is a different team with Christian McCaffrey toting the rock. SF is the play.

2022 NFL Week 10 Pick: San Francisco 49ers

Washington Commanders vs. Philadelphia Eagles

  • When: Monday, November 14th, 2022. 8:20pm EST.
  • Where: Lincoln Financial Field, Philadelphia, PA
  • NFL Odds: Chargers (+11.5) // 49ers (-11.5)

Few teams go 9-0 in the NFL. Wait, didn’t we write that few teams go 8-0? Oh, yeah. In any case, the Eagles offer way too many points to a rival that’s playing good ball.

Washington had Minnesota on the ropes. D.C. couldn’t close the deal. We’re not saying the Commanders win, but this will be a tough game.

2022 NFL Week 10 Pick: San Francisco 49ers

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*All stated odds are subject to change without prior notice.